It is commonly assumed that generalized complaints are not very serious, or that if a patient complains of a multitude of complaints, then no single complaint must be bothering him very much. Neither of these assumptions is necessarily correct. As mentioned in previous chapters, medical problems that affect lower levels of organization of the body tend to be more difficult to measure with our current technology and tend to cause more generalized complaints. So, some might assume that because a condition is difficult to quantitate or measure exactly with available technology, the resulting generalized complaints can't be very severe. But, it must not be assumed that the symptoms of Wilson's Temperature Syndrome are mild and insignificant. They are severe, inappropriate, and undesirable enough for WTS sufferers to be given all manner of symptomatic therapies in an attempt to address them.

Sometimes patients will come to my office on five or six different symptomatic medicines for five or six different symptoms that are related to Wilson's Temperature Syndrome. These medicines can often be discontinued when the body temperature patterns have been normalized without return of the symptoms even after the WT3 protocol has been weaned. Of course, not every symptom of which a person complains is necessarily due to thyroid hormone deficiency. But we have discussed in previous chapters, why DTSF especially due to Wilson's Temperature Syndrome, should be one of the first possibilities considered. It is very common, very easy to recognize, very easy to treat, and getting it treated can make all the difference in a person's life. Considering the pervasive influence of thyroid hormones on the body, and considering thyroid hormone function can affect all aspects of life including recovery from illness, emotional make up, productivity, and overall good health, it stands to reason that special attention should be paid to the possibility of DTSF-especially since it can affect the way a patient responds to treatments for other medical problems that may also be present. Finally, Wilson's Temperature Syndrome and other causes of DTSF should always be considered in patients suffering from symptoms of MED since it is better to treat the underlying problem rather than just the symptoms.

I will now review symptomatic treatments that are commonly implemented by doctors to treat the symptoms of Wilson's Temperature Syndrome. There are a few things that the following treatments have in common. I have seen each of them used in the treatment of symptoms of Multiple Enzyme Dysfunction in Wilson's Temperature Syndrome sufferers prior to their being treated with proper liothyronine therapy. When the symptom a certain treatment is managing returns after the treatment is discontinued, it is more likely that the treatment is symptomatic. It has also been seen in some cases, that the patients' symptoms responded at least as well if not better to proper thyroid hormone therapy as compared with the symptomatic treatment; with the symptoms remaining persistently improved after the symptomatic therapy had been discontinued and even after the thyroid hormone therapy had been weaned. So proper liothyronine treatment can be a symptomatic treatment (managing the symptoms during treatment), and even a therapeutic one (effecting a persistent "cure").

We will now discuss symptomatic treatments commonly given for the symptoms of Wilson's Temperature Syndrome which often respond better to proper thyroid hormone treatment. The following are common symptomatic treatments:
 

Given for the treatment of allergies, hay fever, sinus congestion, and other associated complaints. Again, when one finds out through careful history that the patient's hay fever or allergies came on together in a group after a major stress several years ago, and its onset correlated with that of several other symptoms of Wilson's Temperature Syndrome, it is possible that the complaints are related to DTSF and low body temperature patterns. This is especially true when the allergy and hay fever symptoms resolve together with the other symptoms of Wilson's Temperature Syndrome quickly and predictably after normalization of body temperature patterns with the WT3 protocol.
 

Given for acid indigestion and ulcer formation that develop secondary to decreased bowel motility which caused decreased stomach emptying and greater build up of acids in the stomach. Many times patients can be easily weaned off ulcer medication, and enjoy resolution of their heartburn and indigestion problem once their body temperature and bowel motility have been returned to normal with proper thyroid hormone treatment.
 

Given for the lightheadedness, clumsiness, and sensation of being "off balance" that frequently resolve better with proper thyroid hormone treatment.
 

Patients frequently take prescription and over-the-counter anti-inflammatory medicines for menstrual cramps and arthritis that can be associated with Wilson's Temperature Syndrome. The menstrual cramps are often easily resolved with proper thyroid hormone treatment.
 

Given for the respiratory, urinary, skin, and yeast infections that are commonly associated with Wilson's Temperature Syndrome. Recurring and difficult to treat infections such as acne, yeast infections, skin, and wound infections can frequently be eliminated with proper thyroid hormone treatment and normalization of body temperature patterns.
 

Given sometimes for the depression that is related to Wilson's Temperature Syndrome. They are also sometimes given with the intention of treating the muscular aches or fibromyalgia that is sometimes associated with WTS . The antidepressants are also sometimes prescribed in an attempt to address the associated anxiety and panic attacks.
 

Inappropriate weight gain has long been recognized as a characteristic of hypothyroidism (one cause of DTSF). This symptom of DTSF can present in the same fashion as other DTSF symptoms caused by Wilson's Temperature Syndrome. It can appear or worsen after a major stress, be related to one or many of the other symptoms of Wilson's Temperature Syndrome; and be well correlated with a consistently low body temperature pattern. A patient's weight can depend on their diet, exercise, female hormones, adrenal hormones, and thyroid hormones as well as body shape and stress levels. Of course, not all of these factors can be controlled with thyroid hormone medication. However, it has long since been made clear that decreased thyroid system function can greatly affect a patient's ability to maintain normal weight. If a person's DTSF is overlooked when approaching their weight problem, the approaches taken may not fully address the underlying problems. Such approaches, therefore, often result in the gaining back of the patient's weight after the approaches have been discontinued. Since Wilson's Temperature Syndrome is essentially a starvation coping mechanism gone amuck, severe dieting can actually make the problem worse causing the patient to gain all the weight back and then some. If people are having a problem maintaining their weight, it would be worth taking a careful history to see if the patient's weight problems came on after a major stress together with other symptoms of Wilson's Temperature Syndrome and a low body temperature pattern (WS?).
 

Even though these are cosmetic issues, they deserve to be mentioned because of the impact that they can have on a patient's life, financially and emotionally. Many, many of the female patients that I treat for Wilson's Temperature Syndrome have artificial nails because of the splitting, breaking, peeling, and lack of growth of their own nails. Patients will often wear wigs or toupees due to hair loss. Patients may sometimes require a repeat perm after their permanent falls out within two weeks, when their permanents usually stay in for months (before Wilson's Temperature Syndrome). Sometimes the perm may not take at all. This problem is often corrected with proper thyroid hormone treatment. Interestingly, the dry and brittle hair problem that is frequently associated with Wilson's Temperature Syndrome sometimes begins to clear up in a manner of days, even two to fourteen days. Since the hair certainly has not had time to grow out completely within a period of two weeks, it appears that the condition and quality of the hair must have something to do with the oils that are secreted from the scalp. Frequently, with proper thyroid hormone treatment the change in the hair can often be dramatic and noticeable leaving it more manageable even within a period of two weeks. Some of the changes come over time as the hair grows out but it is interesting that some of the hair complaints improve in such a short period of time. (See PIGMENTATION, SKIN AND HAIR, CHANGES in Chapter 9).
 

Asthma is not commonly considered to be related to DTSF. However, that it can be related has been seen to the extent that the asthma associated with Wilson's Temperature Syndrome frequently follows the pattern of onset and resolution of the other symptoms of Wilson's Temperature Syndrome (coming on together in a group after a stress and resolving with that group with proper thyroid treatment). The asthma, when untreated, can be quite severe at times with some patients even being hospitalized and requiring maintenance asthma medicine therapy to control their symptoms. Again, careful history can provide clues that a person's asthma may be related to Wilson's Temperature Syndrome. Asthma is frequently a disease of childhood that people outgrow, but Wilson's Temperature Syndrome patients sometimes first develop asthma in adulthood. Whether the symptoms of asthma begin in childhood or adulthood, the patient should always be asked if they presented after a major stress and if they came on in association with any of the other symptoms of MED caused by low body temperature patterns, to see, if by chance, the asthma may be related to Wilson's Temperature Syndrome. Many times these patients respond much better to thyroid hormone treatment than they do to asthma medicines, especially in the sense that their asthma sometimes stays persistently improved even after treatment has been discontinued. I have seen many patients who, when I first saw them, had been taking asthma medicine for years (even 10 to 20 years). Upon careful history one sometimes finds that these patients' asthma began after they were having a period of severe marital problems, financial collapse, or other severe stress, with their asthma persisting even after the stress had passed. Many of these patients have been able to wean off their asthma medicine (beta-agonist pills and bronchodilator inhalers) even completely. Their asthma sometimes even remains persistently improved even after the thyroid hormone treatment has been gradually tapered off and discontinued.
 

Frequently given to help regulate irregular periods or to treat heavy menstrual periods. In this setting, the birth control therapy frequently does help. The irregular periods and heavy menstrual cycles can sometimes be corrected to such an extent that they even remain corrected even after therapy has been discontinued. Sometimes, however, the irregular menstrual cycle and heavy periods resume once birth control pill therapy has been discontinued. Proper thyroid hormone treatment can often be used in Wilson's Temperature Syndrome patients to treat the irregular periods and heavy menstrual cycles with there being persistent improvement even after the therapy has been discontinued. So, in cases where irregular menstrual cycles and heavy periods do not remain persistently improved after birth control therapy has been discontinued, persistent improvement might be accomplished through the use of thyroid hormone therapy (in Wilson's Temperature Syndrome sufferers).
 

Sometimes patients with Wilson's Temperature Syndrome have scars on their wrists where they have undergone surgery to release the ligament that overlies the carpal tunnel. The carpal tunnel is the bony tunnel at the base of the hand through which many of the hand's most important blood vessels, nerves, and tendons pass. The Carpal Tunnel Syndrome surgery is done to release the pressure that results from fluid retention in the tissues of the confined space that causes pinching of the nerves, and numbness and tingling of the hands. Carpal Tunnel Syndrome has long been associated with hypothyroidism. Again, however, DTSF is commonly overlooked because of over reliance on thyroid hormone blood tests. A patient presented to my office with a scar on her right wrist and numbness and tingling of her left hand. The scar on her right wrist was from the successful Carpal Tunnel Syndrome surgery that had relieved the numbness and tingling of her right hand which she had had previously. When I first saw her, she was having the identical problem with her left hand. She had already been scheduled for surgery that was to be done thirty days after our first meeting. Since her related symptoms, signs, and story were so characteristic of Wilson's Temperature Syndrome, it was recommended to her that she postpone her Carpal Tunnel Syndrome surgery until after a therapeutic trial on thyroid hormone treatment. Within the month the numbness and tingling of her hand resolved with normalization of her body temperature patterns and she canceled her Carpal Tunnel Syndrome surgery.
 

Because patients are sometimes unable to get their cholesterol levels down to a normal level in spite of diligent dieting and exercise.
 

Wilson's Temperature Syndrome patients are sometimes treated with cortisone for arthritis, asthma, and hair loss. Low body temperature patterns frequently can lead to fluid retention or swelling that can result in aches and pains of the muscles and joints; for which patients are sometimes treated with cortisone. It is interesting that cortisone is well known to inhibit 5'-deiodinase (the enzyme that converts T4 to T3) directly. Understandably then, cortisone therapy has been seen to precipitate or bring on cases of Wilson's Temperature Syndrome as well as worsen existing cases. Cortisone therapy can often be quite useful in the treatment of arthritis, asthma, and hair loss (frequently given by injection into the scalp). However, sometimes these problems can respond much better to thyroid hormone therapy than to cortisone therapy as can the other related symptoms of Wilson's Temperature Syndrome. Careful history can frequently correlate the onset of these symptoms with the clinical picture of Wilson's Temperature Syndrome (beginning after a major stress, associated with low body temperature patterns, and responding very well with normalization of the body temperature patterns).
 

Frequently given for fluid retention.
 

Wilson's Temperature Syndrome sufferers sometimes develop ringing in the ears that begins or worsens after a significant stress. Ringing in the ears typically gets worse with the onset of fluid retention symptoms and gets better with the resolution of fluid retention. These patients frequently have undergone a number of evaluations and sometimes treatments for their ringing in the ears without success. In several cases that I have seen, these patients can have very disturbing, almost maddening ringing in the ears that responds quite well to proper thyroid hormone treatment, even with complete resolution of this disturbing complaint.
 

It is well known that one of the first things that should be checked in a patient being treated for infertility is their thyroid function. Unfortunately, too much attention is often focused on the thyroid gland rather than the thyroid system. The possibility of decreased thyroid system function is often dismissed if thyroid hormone blood tests are normal even in the face of classic DTSF symptoms. Sometimes fertility drugs can even worsen the situation in Wilson's Temperature Syndrome, causing initiation or worsening of the symptoms of Wilson's Temperature Syndrome; sometimes, with the symptoms remaining persistently worse even after the fertility medicine has been discontinued. Quite a few patients I have treated have conceived easily when they had previously had difficulty getting pregnant. Of course, Wilson's Temperature Syndrome patients often have a history of one or more miscarriages. Proper thyroid hormone treatment is sometimes necessary to enable these patients to conceive and maintain a pregnancy.
 

Since patients with Wilson's Temperature Syndrome frequently have hypoglycemia, they are frequently advised to eat six small meals per day (rather than three) that are a little higher in protein and a little lower in carbohydrates. Indeed, this is good advice since it does alleviate fairly well the symptoms of hypoglycemia and it does decrease the body's incentive to slow down further into conservation mode. The less time the stomach is empty, perhaps the less inclined the body is to perceive itself as starving. I remember one case in particular when a patient developed the symptoms of Wilson's Temperature Syndrome (including hypoglycemia) and a low body temperature pattern after a major stress. Upon discussing the pros and cons, risks, and benefits of the alternative treatments, it was decided that the patient should employ a hypoglycemic diet initially. Interestingly, she was able to bring herself out of the conservation mode and back into the productivity mode through the use of her hypoglycemic diet, which is possible in some cases. However, in the many cases that hypoglycemic dieting and proper exercise alone are unable to reverse the patient's tendency for hypoglycemia (due to Wilson's Temperature Syndrome), normalization of body temperature patterns through the use of proper thyroid hormone treatment frequently will.
 

Decreased thyroid system function and resulting low body temperature patterns can cause decreased bowel motility which can manifest itself in several ways. It can lead to constipation, which constipation is frequently treated with various types of laxatives, including bulk-forming laxatives and suppositories. Patients can frequently go three to five days without a bowel movement and sometimes as long as three weeks. This constipation is often treated with high fiber diets, bulk-forming laxatives, and stool softeners. The constipation can also lead to straining-at-the-stool and consequent hemorrhoid formation which is often treated with creams and other preparations. The abnormal bowel motility and constipation sometimes leads to reflexive spasms, abdominal pain, cramping, gas, and even diarrhea. This situation is commonly referred to as Irritable Bowel Syndrome or Spastic Colon. Patients with Wilson's Temperature Syndrome often have constipation and/or diarrhea with gas, bloating, and cramping. I remember one patient who was suffering from acid indigestion, constipation, and hemorrhoids because of his decreased bowel motility. He was taking histamine blockers (ulcer medicine) for his acid indigestion. He was on a bulk-forming laxative to prevent constipation, and he was requiring a steroid hemorrhoid cream for his hemorrhoids. With proper thyroid hormone treatment, his bowel motility returned to normal. His tendencies for constipation and acid indigestion also resolved. And he was no longer bothered with hemorrhoids. He was able to wean off his ulcer medicine, laxative, and hemorrhoid medicine as well as the thyroid hormone treatment.

Antispasmodic medicines are frequently given for the spastic colon symptoms to help patients with gas, bloating, and sudden episodes of diarrhea. One such unfortunate patient can remember, to the day, when his case of severe spastic colon began (a day of severe job stress). From that day, he had symptoms of Irritable Bowel Syndrome so severe that he had been unable to enjoy some of his favorite pursuits (piloting an airplane and scuba diving). Doctors were unable to find the cause of his Irritable Bowel Syndrome and were treating him with antispasmodic/anti anxiety medications, which improved his situation but did not correct it. With the WT3 protocol, the patient's symptoms of spastic colon resolved quickly (several weeks), and dramatically, with normalization of his bowl motility. His situation was far better treated with proper thyroid therapy than with the less successful antispasmodic therapy.
 

Wilson's Temperature Syndrome patients often benefit from marriage and family counseling for the interpersonal relationship problems that can sometimes result due to the symptoms of MED caused by low body temperature patterns. However, this counseling can sometimes be disappointing in that it cannot always get to the underlying problem. I have seen cases where proper thyroid hormone treatment resulted in such an improved level of well-being and restored emotional resources that the patient and patient's family were able to enjoy much more appropriate interpersonal relationships-so much so that the need for marriage and family counseling was obviated. It is truly amazing to see how much Multiple Enzyme Dysfunction resulting from low body temperature patterns caused by Wilson's Temperature Syndrome can affect the attitudes of people, the way they feel about themselves and other people, and the way they interact and get along with other people. It can literally be as great as the difference between night and day.
 

Patients are frequently treated with long lists of different headache medicines for the troublesome and debilitating headaches, and even severe migraines that can be associated with Wilson's Temperature Syndrome. These medicines include aspirin, acetaminophen, ibuprofen, and an assortment of migraine headache medicines (beta-blockers, calcium channel-blockers, ergotamines, and narcotic pain medicines). One dramatic case that I remember involved a woman who was diagnosed as having severe basilar artery migraine headaches that would cause severe headache pain, nausea and vomiting, and even neurological changes that would cause numbness and/or weakness of her face, mouth, and hands. Her migraines were so severe at times they would leave her almost unresponsive. During such episodes she would often be taken to the hospital and given oxygen therapy which would sometimes help. Since her headaches were so frequent and so severe, she actually was given a prescription for oxygen tanks that she could keep at home for this purpose. When the migraine headaches became very severe she would sometimes use oxygen at home to provide her brain with sufficient oxygen. She has undergone every available migraine headache treatment from pain medicines, to the blood pressure medicines that are frequently used for migraine headaches (beta-blockers and calcium channel-blockers). She has even been given an experimental treatment involving a blood thinner. She was given a treatment wherein a blood thinner was aerosolized into a fine mist which she would then inhale in an attempt to alleviate the migraines. This treatment would help but it would not correct her severe migraine headaches. To the patient's utter dismay her migraine headaches responded quickly and dramatically to proper thyroid hormone treatment and body temperature pattern normalization. She has not had a severe headache since the time she was started on thyroid hormone therapy, when she was to the point of having these headaches every several days if not every day. Not only has she not had a severe headache but she hasn't had any (other than those easily relieved with very mild analgesic medicine, such as aspirin). In this patient's case, and in many others, the thyroid hormone treatment wasn't just helpful in the treatment of migraines -- but essentially eliminated them.
 

Wilson's Temperature Syndrome can result in muscle and joint aches, poor healing of musculoskeletal problems, and pinched nerve syndromes. Many things can cause muscle and joint pain, and pinched nerves. Thyroid system impairment is not an exception. The musculoskeletal complaints associated with Wilson's Temperature Syndrome often seem to be related in some way to fluid retention. Since Wilson's Temperature Syndrome is so easily treated and can have such a profound affect on the musculoskeletal system, it is a condition well worth considering. It can explain why some patients recuperate much more slowly than others from surgeries or accidents because of significant fluid retention and inflammation which can impair proper healing. The presence of Wilson's Temperature Syndrome can also explain, therefore, why some patients do not respond as favorably to orthopedic physical therapy and chiropractic therapy as well as others.
 

Frequently given for premenstrual syndrome symptoms and for symptoms that are suspected to be menopausal in origin. PMS symptoms will frequently respond, to an extent, to progesterone therapy since progesterone can affect body temperature patterns as can thyroid hormones. Frequently, however, the symptoms will not thoroughly respond to progesterone therapy and do not often remain persistently improved after that therapy is discontinued. One major difficulty with female hormone therapy is that there are a great number of variables to be considered. Usually, the greater the number of variables, the more complicated and the less predictable a certain treatment is. For example, it would be hard to direct therapy, since the female hormone system has a cyclical (monthly) influence on the body temperature pattern and it would be hard to predict when it should go up and when it should go down. And, there are both progesterones and estrogens which can be given in many different combinations and it is hard to predict what influence those combinations will have. There are also many different brands and forms of estrogens and progesterones, some of which are not found in nature. When the symptoms return after the progesterone therapy has been discontinued (even if the symptoms were improved with progesterone therapy), it makes it more likely that the treatment was affecting the symptoms rather than the underlying problem. PMS resulting from Wilson's Temperature Syndrome will frequently remain improved even after treatment has been discontinued.
 

Paradoxically some patients with Wilson's Temperature Syndrome who suffer from fatigue during the day also complain of insomnia or difficulty sleeping at night. These patients are often treated with sleeping pills that control the insomnia with varying degrees of success, sometimes not working at all. Many of these patients return to having normal energy during the day and sleeping very soundly at night once their body temperature patterns are returned to normal.
 

Wilson's Temperature Syndrome patients can be more susceptible to poor wound healing and infection. In severe cases, they may report having had to undergo a surgical revision of a surgical wound several days or weeks after a previous surgery due to poor wound healing or infection. Sometimes the wound healing is so poor that the wound may literally fall apart and/or tear open again. Patients who have had to undergo these revisions often relate classic histories consistent with Wilson's Temperature Syndrome. Of course, surgery itself can precipitate the onset of Wilson's Temperature Syndrome. So a person might undergo a surgery so physically stressful that it precipitates Wilson's Temperature Syndrome, making it difficult for the patient to heal and recuperate properly from the operation. With proper thyroid hormone treatment, wound healing often improves tremendously, as well as one's ability to fight off infection. It is easy to understand how Wilson's Temperature Syndrome sufferers might have greater complications and longer hospital stays after surgical procedures than are typical and expected. This single problem accounts for a huge amount of cost in terms of longer hospital stays, very expensive antibiotics, and repeat surgeries. Not only can it be disappointing and unfavorable to the patient's physically, but financially as well.
 

I am including thyroid hormone medications as symptomatic therapies (as opposed to therapeutic) frequently given to patients with Wilson's Temperature Syndrome who would frequently respond better to proper thyroid hormone therapy (especially the WT3 protocol). This is to underscore the fact that the choice of thyroid hormone medication must, in every case, be based on the underlying cause of DTSF suspected in each individual patient. As we discussed previously, there are different causes of DTSF and they are not all best treated in the same way. Even patients having the same cause of DTSF, should be treated on a tailored individual case basis. For example, even though three different people each drive separately from the same apartment building to the same grocery store by car, their paths should be individualized depending on red lights, green lights, roads taken, curbs, pedestrians, traffic, lane changes, and other important factors. Some patients may be suffering from two causes of DTSF at the same time. Patients suffering from DTSF frequently do not respond completely to the thyroid hormone regimen they are being prescribed because it may not be adequately addressing the underlying cause or causes. Likewise, if the symptoms do improve to an extent, they may return after treatment has been discontinued; whereas, they might remain persistently improved if the proper thyroid hormone treatment is prescribed.

One such example is the frequent situation that occurs when a patient suffering from Graves' Disease (hyperthyroidism) undergoes complete removal or destruction of the thyroid gland in order to correct this, sometimes life-threatening, over-active thyroid gland problem. After the removal or destruction of the gland, the patient will be dependent on thyroid hormone medication for life. Such patients are frequently started on T4 preparations. As one might imagine, however, developing a serious illness which results in the removal of one's thyroid gland can be a rather stressful experience. Consequently, such patients may not satisfactorily convert the T4 medication they are given which can leave them with some very disturbing complaints of DTSF. Prior to developing Graves' Disease such a patient may have been completely healthy without any problems or health complaints of any kind, then the patient develops symptoms of an overactive thyroid system for which the patient requires treatment. After treatment, the patient may be left with symptoms of underactive thyroid system function in spite of being treated with thyroid hormone medication. So, in spite of treatment, the patient is left with disturbing symptoms of DTSF which were not present before the patient's development of Graves' Disease. However, with the WT3 protocol, the former Graves' Disease patient's DTSF, due to Wilson's Temperature Syndrome (impaired conversion of the T4 medication prescribed), may be corrected. Once the T4 to T3 conversion impairment is corrected with the WT3 protocol, the Graves' Disease patient can frequently be switched back to T4 therapy and enjoy persistent correction of the symptoms of DTSF, and once again return to feeling much the way he or she felt prior to developing Graves' Disease.
 

Wilson's Temperature Syndrome can sometimes lead to feelings of anxiety and even panic attacks. Some patients present to my office being treated with tranquilizers and antianxiety medications. These medicines are often extremely helpful to control the symptoms, but do not treat the problem, when the problem is impaired T4 to T3 conversion with resulting low body temperature patterns. One such patient had developed anxious feelings and quite severe panic attacks that would greatly hinder her normal daily functioning. Her symptoms, characteristically, came on together with a group of other related symptoms after a major physical and emotional stress. She had been plagued with these attacks for years and within two weeks of proper thyroid hormone therapy, her panic attacks resolved completely to her astonishment and delight.
 

Patients with DTSF often find their symptoms to be improved with vitamin supplementation and these patients can often be quite knowledgeable on vitamins. Although they sometimes feel much better with vitamin therapy, they do not always return completely back to normal; nor do their improvements generally persist after vitamin therapy had been discontinued. These patients will frequently respond better to treating the underlying problem with proper thyroid hormone treatment. It may be that Wilson's Temperature Syndrome affects intestinal absorption or body utilization of vitamins, so supplementation with vitamins is often quite helpful. However, after body temperature patterns have been normalized the patients' symptoms of fatigue, depression, dry skin, dry hair, brittle nails, etc., frequently remain improved even after vitamin therapy and thyroid hormone therapy have been weaned.