Many patients with symptoms of low thyroid function respond dramatically well to the treatment described in this Doctor's Manual even though their thyroid blood tests are completely normal.
 

Every other low thyroid problem has to do with how well thyroid hormone is delivered to the tissues. WTS has to do with how well those hormones are processed in the tissues after they get there (regardless of whether those hormones are produced by the body or from medicine, in other words people on T4-containing thyroid medicine may still not feel well if those hormones aren't being processed well in the tissues. The blood stream is the "mailman" that delivers to the tissues the thyroid hormones that have been shipped from the glands (or thyroid medicine). The blood tests can't show how well your tissues process thyroid hormones any better than the mailman can say for sure what happens to all the mail he delivers. He has a good idea of what's supposed to happen, but he doesn't know for sure exactly what does happen. The T4 produced in the thyroid gland is not the active form of thyroid hormone. T3 is the active form of thyroid hormone. Most T3 is made from T4 in the tissues of the body, after T4 leaves the blood stream. Poor processing of thyroid hormones in the tissues (invisible to blood tests) can easily explain why some patients with normal tests This explains why patients with normal thyroid tests and even patients with high free T3 and/or Total T3 levels, or low RT3 levels can still respond fantastically well to the treatment.
 

Remarkably, patients' temperatures and symptoms often remain improved even after the T3 therapy has been discontinued. This is an encouraging sign that suggests the treatment is corrective, not palliative. We call this the "resetting phenomenon." There is a precedent for this sort of hormonal correction. Women with irregular periods are often cycled on birth control pills to regulate their periods. When they are weaned off the oral contraceptives after a time, their periods often remain regular. Just as female hormone pills may be correcting female hormone imbalances, trials of T3 therapy may be correcting a thyroid hormone imbalance (a complete paradigm for which is presented in this Doctor's Manual).
 

Low body temperatures as well as other signs and symptoms of low thyroid function, which are unexplained by thyroid blood tests, characterize Wilson's Temperature Syndrome.
 

Stress, such as childbirth or the death of a loved one, can especially bring on the symptoms. Around 80% of Wilson's Temperature Syndrome patients are women. WTS appears to be more common in patients whose ancestors survived famine (e.g., Irish, American Indian).
 

Involves the use of pure T3 powder mixed with a sustained release agent usually administered in capsules. Patients take increasing doses according to a schedule and their signs and symptoms. After the signs and symptoms resolve, the treatment can be tapered off after a time. Sometimes more than one "cycle" of treatment is needed to fully correct the problem. The paradigm of WTS has shaped it's treatment, and the treatment that's fully described in this Doctor's Manual goes a long way to confirm and define the problem.